Simultaneous recordings of sleep-wake activity and of serotonergic metabolism in the medial preoptic area were performed in freely moving rats after the intracerebroventricular injection of interleukin-1 (IL-1) at dark onset. IL-1 (2.5 ng) induced a biphasic increase in slow-wave sleep and an early increase in serotonergic metabolism starting 30 min postinjection. Phasic, state-specific changes (which have been described in spontaneous sleep) were superimposed on this tonic, overall increase in serotonergic metabolism. IL-1 (25 ng) induced an increase in wakefulness and a delayed increase in serotonergic metabolism, which started 120 min postinjection. This suggests that the time course of the serotonergic activation could play a role in mediating IL-1 effects on sleep. Both doses of IL-1 induced a similar and significant increase in brain cortical temperature, suggesting that IL-1 effects on sleep are not a secondary effect of the increase in cortical temperature and that the serotonergic system is not involved in IL-1-induced fever.
Interleukin-1 induces changes in sleep, brain temperature, and serotonergic metabolism / C. Gemma, L. Imeri, M. DeSimoni, M. Mancia. - In: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. - ISSN 0363-6119. - 272:2(1997), pp. R601-R606.
Titolo: | Interleukin-1 induces changes in sleep, brain temperature, and serotonergic metabolism |
Autori: | IMERI, LUCA (Secondo) MANCIA, MAURO (Ultimo) |
Parole Chiave: | 5-hydroxyindole acetic acid; cytokine; rat; sleep-wake cycle; thermoregulation |
Settore Scientifico Disciplinare: | Settore BIO/09 - Fisiologia |
Data di pubblicazione: | 1997 |
Rivista: | |
Tipologia: | Article (author) |
Appare nelle tipologie: | 01 - Articolo su periodico |