To clarify which muscarinic receptor subtype(s) mediate changes in sleep and cortical temperature (T-cort) induced by carbachol microinjections into the medial preoptic area (MPA), pirenzepine, tripitramine and +/-p >$($) over bar-fluoro-hexahydro-sila-difenidol (p-F-HHSiD), which are highly selective muscarinic M(1), M(2) and M(3) antagonists, respectively, were microinjected into the MPA of rats. Whereas pirenzepine (3.45 and 7.08 nmol) and p-F-HHSiD (3.90 and 7.80 nmol) were without effect, tripitramine (0.67 and 3.37 nmol) enhanced wakefulness, decreased slow wave and desynchronized sleep, and raised T-cort with the higher dose. The data suggest that in the MPA only M(2) muscarinic subtypes may be functionally important in mediating the cholinergic effects on sleep and thermoregulation.

Muscarinic receptor subtypes in the medial preoptic area and sleep-wake cycles / L. Imeri, S. Bianchi, P. Angeli, M. Mancia. - In: NEUROREPORT. - ISSN 0959-4965. - 7:2(1996), pp. 417-420.

Muscarinic receptor subtypes in the medial preoptic area and sleep-wake cycles

L. Imeri
Primo
;
S. Bianchi
Secondo
;
M. Mancia
Ultimo
1996

Abstract

To clarify which muscarinic receptor subtype(s) mediate changes in sleep and cortical temperature (T-cort) induced by carbachol microinjections into the medial preoptic area (MPA), pirenzepine, tripitramine and +/-p >$($) over bar-fluoro-hexahydro-sila-difenidol (p-F-HHSiD), which are highly selective muscarinic M(1), M(2) and M(3) antagonists, respectively, were microinjected into the MPA of rats. Whereas pirenzepine (3.45 and 7.08 nmol) and p-F-HHSiD (3.90 and 7.80 nmol) were without effect, tripitramine (0.67 and 3.37 nmol) enhanced wakefulness, decreased slow wave and desynchronized sleep, and raised T-cort with the higher dose. The data suggest that in the MPA only M(2) muscarinic subtypes may be functionally important in mediating the cholinergic effects on sleep and thermoregulation.
selective muscarinic antagonist; pirenzepine; tripitramine; p-fluoro-hexahydro-sila-difenidol; rat; thermoregulation
Settore BIO/09 - Fisiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/187542
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