The synthesis, through a cross-metathesis reaction, of the first chiral peptide nucleic acid (PNA) monomer labelled with a Fischer-type carbene complex of chromium is reported. IR analysis of the new bioconjugate shows that the Cr(CO)4 moiety represents a suitable spectroscopic probe for diagnostic purposes.
Synthesis of the first chiral PNA monomer labeled with a Fischer-type carbene complex / S. Maiorana, E. Licandro, D. Perdicchia, C. Baldoli, B. Vandoni, C. Giannini, M. Salmain. - In: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL. - ISSN 1381-1169. - 204-205(2003), pp. 165-175.
Synthesis of the first chiral PNA monomer labeled with a Fischer-type carbene complex
S. MaioranaPrimo
;E. LicandroSecondo
;D. Perdicchia;C. GianniniPenultimo
;
2003
Abstract
The synthesis, through a cross-metathesis reaction, of the first chiral peptide nucleic acid (PNA) monomer labelled with a Fischer-type carbene complex of chromium is reported. IR analysis of the new bioconjugate shows that the Cr(CO)4 moiety represents a suitable spectroscopic probe for diagnostic purposes.
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