To study the role of muscarinic receptor subtypes in sleep control, methoctramine (25, 50, 75-mu-g), a highly selective M2 antagonist, was injected intra-cerebroventricularly into freely moving rats. Methoctramine induced a dose-dependent increase in desynchronized sleep (DS) latency (from 62.7 +/- 10 min following saline to 122.4 +/- 13.8 min with the lowest dose) and a 75% decrease in the amount of DS in 6 h recordings. 4DAMP (a M3/M1 selective antagonist) did not significantly change DS latency and percentage time, but it reduced wakefulness (from 38 +/- 2.8% following saline to 25.3 +/- 3.7% with a dose of 2.5), and increased slow wave sleep. The results suggest that M2 muscarinic receptors play a selective role in DS physiology.
DIFFERENTIAL-EFFECTS OF M2 AND M3 MUSCARINIC ANTAGONISTS ON THE SLEEP-WAKE CYCLE / L. IMERI, S. BIANCHI, P. ANGELI, M. MANCIA. - In: NEUROREPORT. - ISSN 0959-4965. - 2:7(1991), pp. 383-385.
Titolo: | DIFFERENTIAL-EFFECTS OF M2 AND M3 MUSCARINIC ANTAGONISTS ON THE SLEEP-WAKE CYCLE |
Autori: | IMERI, LUCA (Primo) BIANCHI, SUSANNA EMMA FRANCESCA (Secondo) MANCIA, MAURO (Ultimo) |
Parole Chiave: | 4-Diphenylacetoxy-N-methylpiperidine methiodide; Acetylcholine; Desynchronized sleep; Methoctramine; Muscarinic receptor antagonists; Sleep-wake cycle |
Settore Scientifico Disciplinare: | Settore BIO/09 - Fisiologia |
Data di pubblicazione: | 1991 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/00001756-199107000-00007 |
Appare nelle tipologie: | 01 - Articolo su periodico |