To study the role of muscarinic receptor subtypes in sleep control, methoctramine (25, 50, 75-mu-g), a highly selective M2 antagonist, was injected intra-cerebroventricularly into freely moving rats. Methoctramine induced a dose-dependent increase in desynchronized sleep (DS) latency (from 62.7 +/- 10 min following saline to 122.4 +/- 13.8 min with the lowest dose) and a 75% decrease in the amount of DS in 6 h recordings. 4DAMP (a M3/M1 selective antagonist) did not significantly change DS latency and percentage time, but it reduced wakefulness (from 38 +/- 2.8% following saline to 25.3 +/- 3.7% with a dose of 2.5), and increased slow wave sleep. The results suggest that M2 muscarinic receptors play a selective role in DS physiology.

DIFFERENTIAL-EFFECTS OF M2 AND M3 MUSCARINIC ANTAGONISTS ON THE SLEEP-WAKE CYCLE / L. IMERI, S. BIANCHI, P. ANGELI, M. MANCIA. - In: NEUROREPORT. - ISSN 0959-4965. - 2:7(1991), pp. 383-385.

DIFFERENTIAL-EFFECTS OF M2 AND M3 MUSCARINIC ANTAGONISTS ON THE SLEEP-WAKE CYCLE

L. IMERI;S. BIANCHI;M. MANCIA
1991

Abstract

To study the role of muscarinic receptor subtypes in sleep control, methoctramine (25, 50, 75-mu-g), a highly selective M2 antagonist, was injected intra-cerebroventricularly into freely moving rats. Methoctramine induced a dose-dependent increase in desynchronized sleep (DS) latency (from 62.7 +/- 10 min following saline to 122.4 +/- 13.8 min with the lowest dose) and a 75% decrease in the amount of DS in 6 h recordings. 4DAMP (a M3/M1 selective antagonist) did not significantly change DS latency and percentage time, but it reduced wakefulness (from 38 +/- 2.8% following saline to 25.3 +/- 3.7% with a dose of 2.5), and increased slow wave sleep. The results suggest that M2 muscarinic receptors play a selective role in DS physiology.
4-Diphenylacetoxy-N-methylpiperidine methiodide; Acetylcholine; Desynchronized sleep; Methoctramine; Muscarinic receptor antagonists; Sleep-wake cycle
Settore BIO/09 - Fisiologia
NEUROREPORT
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/187268
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