Since the thalidomide tragedy, the testing of new drugs on pregnant experimental animals has become a requirement in all countries. Many countries have recently introduced tests for subtle behavioral changes (in the absence of morphological damage). However Flaminio Cattabeni and Maria Pia Abbracchio argue that we do not yet know enough about the significance of these changes to make valid interpretations, or to extrapolate from animals to humans. They also propose that the term 'behavioral teratology' with its negative implications should be replaced by the more appropriate term 'chemical imprinting' to account also for chemicals inducing behavioral effects in animals which do not necessarily cause true neurological damage.

BEHAVIORAL TERATOLOGY - AN INAPPROPRIATE TERM FOR SOME UNINTERPRETABLE EFFECTS / F. CATTABENI, M.P. ABBRACCHIO. - In: TRENDS IN PHARMACOLOGICAL SCIENCES. - ISSN 0165-6147. - 9:1(1988), pp. 13-15.

BEHAVIORAL TERATOLOGY - AN INAPPROPRIATE TERM FOR SOME UNINTERPRETABLE EFFECTS

F. CATTABENI
Primo
;
M.P. ABBRACCHIO
Ultimo
1988

Abstract

Since the thalidomide tragedy, the testing of new drugs on pregnant experimental animals has become a requirement in all countries. Many countries have recently introduced tests for subtle behavioral changes (in the absence of morphological damage). However Flaminio Cattabeni and Maria Pia Abbracchio argue that we do not yet know enough about the significance of these changes to make valid interpretations, or to extrapolate from animals to humans. They also propose that the term 'behavioral teratology' with its negative implications should be replaced by the more appropriate term 'chemical imprinting' to account also for chemicals inducing behavioral effects in animals which do not necessarily cause true neurological damage.
Settore BIO/14 - Farmacologia
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/186865
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 9
social impact