1 Desensitization of lung β-adrenoreceptors induced by 4 day in vivo isoprenaline administration to rats has been investigated both from a functional and a biochemical viewpoint. 2 Chronic isoprenaline treatment significantly reduced the relaxing activity of the β-agonist when tested ex vivo in lung parenchymal strips and also impaired the adenylate-cyclase system. Moreover, the desensitization procedure decreased by about 30% β-adrenoreceptor number. 3 In vivo indomethacin treatment prevented the loss of pharmacological responsiveness of the tissue to isoprenaline and restored basal adenylate-cyclase activity. 4 These data indicate that in vivo isoprenaline administration actually leads to pulmonary β-adrenoreceptor desensitization. The involvement of arachidonic acid metabolites in this phenomenon is also discussed.
FUNCTIONAL AND BIOCHEMICAL MODIFICATIONS OF LUNG BETA-ADRENOCEPTORS AFTER INVIVO DESENSITIZATION - PREVENTION BY INDOMETHACIN / M. FANO, M. ABBRACCHIO, F. CATTABENI, L. DAFFONCHIO, A. HERNANDEZ, C. OMINI. - In: JOURNAL OF AUTONOMIC PHARMACOLOGY. - ISSN 0144-1795. - 6:1(1986), pp. 47-51.
Titolo: | FUNCTIONAL AND BIOCHEMICAL MODIFICATIONS OF LUNG BETA-ADRENOCEPTORS AFTER INVIVO DESENSITIZATION - PREVENTION BY INDOMETHACIN | |
Autori: | ABBRACCHIO, MARIA PIA (Secondo) | |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia | |
Data di pubblicazione: | 1986 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1474-8673.1986.tb00630.x | |
Appare nelle tipologie: | 01 - Articolo su periodico |