Background Chronic heart failure causes disturbances in ventilation and pulmonary gas transfer that participate in limiting peak exercise oxygen uptake (VO2p). The (beta-adrenergic receptor blocker carvedilol improves left ventricular (LV) function and not VO2p. This study was aimed at investigating the pulmonary response to changes in LV performance produced by carvedilol in patients with chronic heart failure. Methods Twenty-one patients with New York Heart Association class II to III heart failure were randomly assigned (2 to 1) to carvedilol (25 mg twice daily, n = 14) or placebo (n = 7) for 6 months. Rest forced expiratory volume (FEV1), vital capacity, total lung capacity, carbon monoxide diffusing capacity, its alveolar-capillary membrane component, pulmonary venous and transmitral flows (for monitoring changes in LV end-diastolic pressure), LV diastolic and systolic dimensions, stroke volume, election fraction, and fiber shortening velocity were measured at baseline and at 3 and 6 months. VO2p' peak ratio of dead space to tidal volume (VD/VTp), ventilatory equivalent for carbon dioxide production (VE/VCO2), and VO2 at anaerobic threshold (VO2at) were also determined. Results FEV1, vital capacity, total lung capacity, carbon monoxide diffusing capacity, and the alveolar-capillary membrane component were impaired in chronic heart failure compared with 14 volunteers and did not vary with treatment. Carvedilol reduced end-diastolic pressure, end-diastolic diameter, and end-systolic diameter and increased election fraction, stroke volume, and fiber shortening velocity without affecting VO2p, VO2at, VD/VTp, or VE/VCO2 at 3 and 6 months. Placebo did not produce significant changes. Conclusions In chronic heart failure cardedilol ameliorates LV function at rest and does not significantly affect ventilation and pulmonary gas transfer or functional capacity. These results suggest that improvement in cardiac hemodynamics with carvedilol does not reverse pulmonary dysfunction. Persistent lung impairment might have some role in the failure of carvedilol to improve exercise performance.
Pulmonary function, cardiac function, and exercise capacity in a follow-up of patients with congestive heart failure treated with carvedilol / M. Guazzi, P. Agostoni, M. Matturri, G. Pontone, M.D. Guazzi. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - 138:3 Pt 1(1999 Sep), pp. 460-7-467.
|Titolo:||Pulmonary function, cardiac function, and exercise capacity in a follow-up of patients with congestive heart failure treated with carvedilol|
GUAZZI, MARCO (Co-primo)
AGOSTONI, PIERGIUSEPPE (Secondo)
GUAZZI, MAURIZIO (Co-primo)
|Parole Chiave:||Respiratory Function Tests; Carbazoles; Heart Failure; Propanolamines; Humans; Hemodynamics; Oxygen Consumption; Lung; Adult; Adrenergic beta-Antagonists; Exercise Tolerance; Middle Aged; Female; Male|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||set-1999|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0002-8703(99)70148-1|
|Appare nelle tipologie:||01 - Articolo su periodico|