BACKGROUND: Nodular prurigo is a chronic dermatitis characterized by very intense pruritus. The treatment is often unsatisfactory. METHODS: Two patients, suffering from chronic, widespread and therapy-resistant nodular prurigo, were treated with cyclosporin in microemulsion. The drug was used orally, at dosage of 3 mg/kg per day for 2 months, followed by 2.5 mg/kg per day for 2 months and by 2 mg/kg per day for 2 months. During the therapy no other topical or systemic drugs were used. RESULTS: In both patients pruritus regressed almost completely within 2 weeks, whereas the morphology of the lesions changed slightly (minimal reduction in infiltration and erythema). The regression of pruritus was followed by a noteworthy improvement in the quality of life. During follow-up, no relapses of pruritus were reported. CONCLUSION: On the basis of this experience, cyclosporin in microemulsion can be successfully used in the treatment of chronic, widespread and therapy-resistant nodular prurigo.
Treatment of nodular prurigo with cyclosporin in microemulsion / S. Veraldi. - In: THE JOURNAL OF DERMATOLOGICAL TREATMENT. - ISSN 0954-6634. - 10:4(1999), pp. 237-239.
|Titolo:||Treatment of nodular prurigo with cyclosporin in microemulsion|
VERALDI, STEFANO (Primo)
|Parole Chiave:||Cyclosporin; Cyclosporin in microemulsion; Nodular prurigo|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||1999|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/09546639909056037|
|Appare nelle tipologie:||01 - Articolo su periodico|