Treatment of pregnant rats with methylazoxymethanol (MAM) induces a marked microencephaly in the offspring. The striatum is one of the brain areas affected by treatment. We show that in striatum there is a 30% loss of dopamine (DA)-dependent adenylate-cyclase activity: this indicates that cells bearing type 1 DA receptors are affected by MAM treatment. Moreover, since kainic acid retains its neurotoxic activity, corticostriatal fibers do not seem to be affected, despite the dramatic reduction of cortex size.
|Titolo:||Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats|
ABBRACCHIO, MARIA PIA (Secondo)
CATTABENI, FLAMINIO NICOLA (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1984|
|Appare nelle tipologie:||01 - Articolo su periodico|