Treatment of pregnant rats with methylazoxymethanol (MAM) induces a marked microencephaly in the offspring. The striatum is one of the brain areas affected by treatment. We show that in striatum there is a 30% loss of dopamine (DA)-dependent adenylate-cyclase activity: this indicates that cells bearing type 1 DA receptors are affected by MAM treatment. Moreover, since kainic acid retains its neurotoxic activity, corticostriatal fibers do not seem to be affected, despite the dramatic reduction of cortex size.

Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats / W. Balduini, M.P. Abbracchio, G. Lombardelli, F. Cattabeni. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 317:1(1984), pp. 133-136.

Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats

M.P. Abbracchio
Secondo
;
F. Cattabeni
Ultimo
1984

Abstract

Treatment of pregnant rats with methylazoxymethanol (MAM) induces a marked microencephaly in the offspring. The striatum is one of the brain areas affected by treatment. We show that in striatum there is a 30% loss of dopamine (DA)-dependent adenylate-cyclase activity: this indicates that cells bearing type 1 DA receptors are affected by MAM treatment. Moreover, since kainic acid retains its neurotoxic activity, corticostriatal fibers do not seem to be affected, despite the dramatic reduction of cortex size.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/186725
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