Non-steroidal anti-inflammatory drugs (NSAID) represent potentially useful agents in the treatment of a number of ocular pathologies, but their intraocular penetration and distribution have not yet been reported. With the aim of clarifying this point, we evaluated the concentrations of the well known NSAID, tenoxicam, in the aqueous and vitreous humors of rabbits treated i.m. with the drug (7 mg/kg). The tenoxicam kinetics in these ocular fluids followed that in plasma with the time-to-peak shifted to higher values in the vitreous (1 h) as compared to that in the aqueous and plasma (40 min). AUC was also higher in the vitreous (10.4 micrograms.h/ml) than in the aqueous humor (2.8 micrograms.h/ml).
Intraocular and plasma kinetics of tenoxicam in rabbits / M. Del Puppo, M. G. Kienle, R. Ratiglia, D. Galimberti, G. Acerbi, L. Boerci, L. Marabini, E. Chiesara. - In: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. - ISSN 0721-832X. - 231:2(1993 Feb), pp. 115-7-117.
|Titolo:||Intraocular and plasma kinetics of tenoxicam in rabbits|
|Parole Chiave:||Vitreous Body; Animals; Aqueous Humor; Piroxicam; Rabbits; Anti-Inflammatory Agents, Non-Steroidal; Tissue Distribution; Male; Female|
|Settore Scientifico Disciplinare:||Settore MED/30 - Malattie Apparato Visivo|
|Data di pubblicazione:||feb-1993|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF00920224|
|Appare nelle tipologie:||01 - Articolo su periodico|