Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.
Failure to eradicate HIV despite fully successful HAART initiated in the first days of life / A. Vigano', D. Trabattoni, L. Schneider, F. Ottaviani, A. Aliffi, E. Longhi, S. Rusconi, M. Clerici. - In: THE JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - 148:3(2006 Mar), pp. 389-391.
Failure to eradicate HIV despite fully successful HAART initiated in the first days of life
A. Vigano';D. Trabattoni;L. Schneider;F. Ottaviani;E. Longhi;S. Rusconi;M. Clerici
2006
Abstract
Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.
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