Valutazione dell'immunogenicità del vaccino influenzale adiuvato con MF59 in un campione di anziani istituzionalizzati

Objective: In elderly people, because of complications, influenza can be a dangerous pathology. In elderly people common vaccination can be less immunogen because of reduction of immunity, and for this reason this study was conducted on an adjuvated vaccine (with MF59) (FLUAD Chiron, Siena) adjuvant), on a population of old people totally or partially non-self-sufficient, institutionalised, to show the immunogenicity of this vaccine. Results: The protection reached, after one month from vaccination, these data of immunizations: for people under 84 the 43,0% was protected for H1N1 and 43,7% for people over 85, protection for H3N2 was respectively 87,2% and 81,2%, finally for B virus protection was respectively 67,4% and 75,0%. Conclusions: These data show how this kind of vaccination could be used to obtain a better protection against influenza in elderly people than common vaccination that have a level of protection commonly under 30%. In the most old people (over 85 yrs) this adjuvated-vaccine is preferable than the non-adjuvated vaccine, also because of less important adverse reactions that are observed for this kind of vaccine in this target of people than in younger people.

nello studio viene valutto su un campione di anziani istituzionalizzati la maggior efficacia del vaccino adiuvato con MF59 in termini di media geometrica dei titoli anticorpali tipo specifici pre e post vaccinazione