In rats, repeated daily ip administrations of a low dose (10 mg/kg) of cocaine HCl (COC) produced enhanced locomotor activity; a higher dose (50 mg/kg) led to seizures (pharmacological kindling). Daily pretreatment with naltrexone (NTX)(2 mg/kg/sc), injected 15 min prior to COC, completely antagonized COC-induced motor and convulsant activity, except on the first day when a potentiation of seizures was observed. Using the same treatment schedule, COC 50 mg/kg failed to induce sensitization to the well known local anesthetic properties evaluated through the loss of abdominal tone; this effect was not reversed by NTX pretreatment. These findings provide further evidence of the modulatory role of the opiate system on cocaine sensitization.
Influence of opioid system on behavioral sensitization induced by cocaine in the rat / M. Sala, D. Braida, M. Colombo, F. Terzi, M.P. Leone, E. Gori. - In: REGULATORY PEPTIDES. - ISSN 0167-0115. - 53:Suppl.1(1994), pp. 199-200. ((Intervento presentato al 24. convegno International Narcotics Research Conference (INRC): Towards a Molecular Basis in Opioid Research tenutosi a Skode, Sweden nel 1993.
|Titolo:||Influence of opioid system on behavioral sensitization induced by cocaine in the rat|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1994|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0167-0115(94)90309-3|
|Appare nelle tipologie:||01 - Articolo su periodico|