La ricerca chimico tossicologica sistematica generica in tossicologia forense. II: considerazioni sull’uso degli indici di ritenzione e dei Δ IR nelle metodiche di saggio gas cromatografico

Values for IR (retention index) and ΔIR (difference between the IR values of a given substance obtained on 2 columns of different polarity) were detd. for ∼50 compds. (mostly drugs) of interest in forensic toxicol., using isothermal conditions at various temps. (120-260°) and with programmed temp. cycles. The column packings used were OV1 and OV17 on Gas-Chrom Q. In general, the ΔIR values were as reproducible as the IR. Both showed little or no dependence on the exptl. conditions under which they were obtained. The ΔIR, which measures the polarity of a compd., may be a significant anal. tool in examg. homogeneous series of substances. The IR, however, esp. if detd. under programmed temp. conditions, may be of more value in detg. the genetic nature of heterogeneous compds. such as those of interest in toxicol. By the methods described here, compds. with IR values of the order of 3000 can be detd.