A concd. soln. (drop formulation) of nifedipine (I) [21829-25-4] was dild. 50-fold (for clin. use) with H2O, exposed for 1-10 min to normal lab illumination, and analyzed for degrdn. products by HPLC. More than 95% of I was still intact after 10 min, a time sufficient for normal diln. The relative std. deviation for the HPLC method was 2.78%.
Study of the light stability of nifedipine in a drop formulation under therapeutic use conditions / V. Gambaro, M. Caligara, E. Pesce. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 124:1(1985), pp. 13-18.
Study of the light stability of nifedipine in a drop formulation under therapeutic use conditions
V. Gambaro;M. Caligara;
1985
Abstract
A concd. soln. (drop formulation) of nifedipine (I) [21829-25-4] was dild. 50-fold (for clin. use) with H2O, exposed for 1-10 min to normal lab illumination, and analyzed for degrdn. products by HPLC. More than 95% of I was still intact after 10 min, a time sufficient for normal diln. The relative std. deviation for the HPLC method was 2.78%.
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