Two new granule prepns. (resin and microencapsulated) of ibuprofen [15687-27-1] were compared in a cross-over double-blind single dose pharmacokinetic study. Eight healthy volunteers, mean age 23 yr, were alternatively given the 2 600 mg granule prepns. in a randomized sequence. The differences between formulations were not statistically significant except for t1/2 which showed a slight clin. not important increase with the microencapsulated granules. The mean relative bioavailability of the microencapsulated vs. resin granules was 93.4%. The gastroresistance of the microencapsulated formulation represents a favorable theor. feature for a further improvement of ibuprofen safety.
Pharmacokinetics of ibuprofen microencapsulated granules / V. Gambaro, M. Caligara, C. Benvenuti, C. Scaroni. - In: IL FARMACO. EDIZIONE PRATICA. - ISSN 0430-0912. - 40:12(1985), pp. 407-414.
Pharmacokinetics of ibuprofen microencapsulated granules
V. Gambaro;M. Caligara;
1985
Abstract
Two new granule prepns. (resin and microencapsulated) of ibuprofen [15687-27-1] were compared in a cross-over double-blind single dose pharmacokinetic study. Eight healthy volunteers, mean age 23 yr, were alternatively given the 2 600 mg granule prepns. in a randomized sequence. The differences between formulations were not statistically significant except for t1/2 which showed a slight clin. not important increase with the microencapsulated granules. The mean relative bioavailability of the microencapsulated vs. resin granules was 93.4%. The gastroresistance of the microencapsulated formulation represents a favorable theor. feature for a further improvement of ibuprofen safety.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
