The single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets were studied in a cross-over study in 6 healthy volunteers (median age 28 yr). The formulations had similar systemic availability. Compared with oral tablets the sublingual route gave a lower peak concn. and a delayed peak time, whereas drops gave a greater max. concn. with a similar peak time. The use of drops is suggested for a more marked initial effect and the sublingual route for easier administration, esp. in the elderly.
The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers / C. Benvenuti, V. Botta, M. Broggini, V. Gambaro, F. Lodi, M. Valenti. - In: THE JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0091-2700. - 37:6(1989), pp. 617-619.
The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers
V. Gambaro;F. LodiPenultimo
;
1989
Abstract
The single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets were studied in a cross-over study in 6 healthy volunteers (median age 28 yr). The formulations had similar systemic availability. Compared with oral tablets the sublingual route gave a lower peak concn. and a delayed peak time, whereas drops gave a greater max. concn. with a similar peak time. The use of drops is suggested for a more marked initial effect and the sublingual route for easier administration, esp. in the elderly.Pubblicazioni consigliate
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