The mobilization of haematopoietic progenitor cells is a multifactorial process, still poorly understood at the molecular level. Mobilized haematopoietic progenitors, as defined by the expression of CD34 cell surface molecule, comprise heterogeneous subpopulations of cells committed to different haematopoietic lineages. Haematopoietic progenitors may be mobilized by chemotherapy alone, haematopoietic growth factors alone, or by chemotherapy plus haematopoietic growth factors. The choice of a mobilization regimen that allows an optimal yield of progenitors with a minimum number of leukaphereses should incorporate, in most patients, a disease-specific chemotherapeutic agent(s) plus a haematopoietic growth factor, to be continued until completion of harvest.

Mobilization of peripheral blood progenitor cells for autografting : chemotherapy and G-CSF or GM-CSF / S. Siena, M. Bregni, A.M. Gianni. - In: BAILLIERE'S BEST PRACTICE IN CLINICAL HAEMATOLOGY. - ISSN 1521-6926. - 12:1-2(1999), pp. 27-39.

Mobilization of peripheral blood progenitor cells for autografting : chemotherapy and G-CSF or GM-CSF

S. Siena;A.M. Gianni
1999

Abstract

The mobilization of haematopoietic progenitor cells is a multifactorial process, still poorly understood at the molecular level. Mobilized haematopoietic progenitors, as defined by the expression of CD34 cell surface molecule, comprise heterogeneous subpopulations of cells committed to different haematopoietic lineages. Haematopoietic progenitors may be mobilized by chemotherapy alone, haematopoietic growth factors alone, or by chemotherapy plus haematopoietic growth factors. The choice of a mobilization regimen that allows an optimal yield of progenitors with a minimum number of leukaphereses should incorporate, in most patients, a disease-specific chemotherapeutic agent(s) plus a haematopoietic growth factor, to be continued until completion of harvest.
Granulocyte Colony-Stimulating Factor ; Hematopoietic Stem Cells ; Granulocyte-Macrophage Colony-Stimulating Factor ; Humans ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Cell Growth Factors ; Antineoplastic Combined Chemotherapy Protocols ; Transplantation, Autologous ; Hematopoiesis
Settore MED/06 - Oncologia Medica
1999
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184558
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