In vitro reaction of 17-OH tabersonine 2a and its 11-OMe analogue 2b with adenine, tri-O-acetyl adenosine, -guanosine and -cytidine under mild conditions, results in covalent adducts by electrophilic attack of reactive C-17 position of the alkaloids on the exocyclic nitrogen.
COVALENT NUCLEOSIDE ADDUCTS OF ASPIDOSPERMA ALKALOIDS / B. DANIELI, G. LESMA, G. PALMISANO, D. PASSARELLA, B. PYUSKYULEV. - In: NUCLEOSIDES & NUCLEOTIDES. - ISSN 0732-8311. - 10:8(1991), pp. 1667-1675.
COVALENT NUCLEOSIDE ADDUCTS OF ASPIDOSPERMA ALKALOIDS
B. DANIELIPrimo
;G. LESMASecondo
;D. PASSARELLAPenultimo
;
1991
Abstract
In vitro reaction of 17-OH tabersonine 2a and its 11-OMe analogue 2b with adenine, tri-O-acetyl adenosine, -guanosine and -cytidine under mild conditions, results in covalent adducts by electrophilic attack of reactive C-17 position of the alkaloids on the exocyclic nitrogen.
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