(-)-Antirhine 2 was synthesized in an efficient and stereocontrolled fashion from the readily available (1R-2S)-cyclohexene dimethanol monoacetate 6. A key step was the regio- and stereoselective Pictet Spengler cyclization of the masked dialdehyde 12 to the indoloquinolizidinone 13.

A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (-)-ANTIRHINE BY CHEMOENZYMATIC APPROACH / B. DANIELI, G. LESMA, M. MAURO, G. PALMISANO, D. PASSARELLA. - In: TETRAHEDRON. - ISSN 0040-4020. - 50:29(1994), pp. 8837-8852.

A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (-)-ANTIRHINE BY CHEMOENZYMATIC APPROACH

B. DANIELI
Primo
;
G. LESMA
Secondo
;
D. PASSARELLA
Ultimo
1994

Abstract

(-)-Antirhine 2 was synthesized in an efficient and stereocontrolled fashion from the readily available (1R-2S)-cyclohexene dimethanol monoacetate 6. A key step was the regio- and stereoselective Pictet Spengler cyclization of the masked dialdehyde 12 to the indoloquinolizidinone 13.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183691
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