To evaluate the clinical significance of hemostatic abnormalities in acute stroke, we studied coagulation and platelet function in 70 patients with recent cerebral infarction or hemorrhage and in 45 age-matched controls. Higher levels of one-stage factor VIII coagulant activity, fibrinopeptide A (FPA), and beta-thromboglobulin were associated with the occurrence of stroke. All hemostatic test results were remarkably similar in patients with ischemic and hemorrhagic stroke. FPA levels and size of the lesion on CT were the only variables independently predicting mortality in a multivariate regression analysis. Our findings demonstrate that hypercoagulability is an important prognostic factor in stroke and lend support to clinical trials of drugs interfering with the coagulation system in the early phase of cerebral ischemia.

Hypercoagulability in acute stroke: prognostic significance / G. Landi, A. D'Angelo, E. Boccardi, L. Candelise, P.M. Mannucci, E. Nobile Orazio, A. Morabito. - In: NEUROLOGY. - ISSN 0028-3878. - 37:10(1987 Oct), pp. 1667-71-1671.

Hypercoagulability in acute stroke: prognostic significance

L. Candelise;P.M. Mannucci;E. Nobile Orazio
Penultimo
;
1987-10

Abstract

To evaluate the clinical significance of hemostatic abnormalities in acute stroke, we studied coagulation and platelet function in 70 patients with recent cerebral infarction or hemorrhage and in 45 age-matched controls. Higher levels of one-stage factor VIII coagulant activity, fibrinopeptide A (FPA), and beta-thromboglobulin were associated with the occurrence of stroke. All hemostatic test results were remarkably similar in patients with ischemic and hemorrhagic stroke. FPA levels and size of the lesion on CT were the only variables independently predicting mortality in a multivariate regression analysis. Our findings demonstrate that hypercoagulability is an important prognostic factor in stroke and lend support to clinical trials of drugs interfering with the coagulation system in the early phase of cerebral ischemia.
Acute Disease; Cerebral Hemorrhage; beta-Thromboglobulin; Antigens; Humans; Blood Coagulation Disorders; Prognosis; von Willebrand Factor; Cerebrovascular Disorders; Factor VIII
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183227
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