Fifty depletedpatients (15% ideal body weight loss) were treated at two different non protein kcal (35 and 50) levels with three different amino acid solutions, while receiving a standard daily nitrogen (N) intake of 0.19 gN/kg. Six groups were studied including one in which 50 kcal were administered with a mixed lipid and glucose system. Daily N balance and amino acid profile, were determined for 5 days in low kcal groups and 10 days in the high kcal groups. Positive N balance was obtained at only low kcal intake with two of the three solutions. Judging from pooled data, N balance was related to phenilalanine (Phe) and Methionine (Met) intake and a minimum intake of 91 mg/kg Phe and 70 mg/kg Met seemed necessary to obtain positive N balance. Increasing kcal reduced Phe and Met needs allowing positive N balance with lower intake. A lower then normal baseline amino acid level was observed for nearly all amino acid [except Isoleucine (Ile) Phe, Met, Lysine (Lys) and Ornitine (Orn)]. During treatment plasma concentration of administered amino acids increased in relation to the administered amount for Valine (Val), Ile, The, Met, Lys, Threonine (Thr), Arginine (Arg), Glycine (Gly), (p < 0.001) Alanine (Ala) (p < 0.025) and Proline (Pro) (P < 0.05). A significant negative correlation with administered kcal was found for Ile, Met, Lys and Arg. Amino acids not administered did not show an homogeneous pattern and, using multiple regression, the variables affecting single amino acid behaviour were identified.
|Titolo:||Dispensable and indispensable amino acid requirements in depleted patients receiving total parenteral nutrition|
IAPICHINO, GAETANO (Primo)
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||feb-1987|
|Digital Object Identifier (DOI):||10.1016/0261-5614(87)90061-6|
|Appare nelle tipologie:||01 - Articolo su periodico|