To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO(2) and 93% N(2). Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested.
Does chloroquine really act through oxidative stress? / D. Monti, N. Basilico, S. Parapini, E. Pasini, P. Olliaro, D. Taramelli. - In: FEBS LETTERS. - ISSN 0014-5793. - 522:1-3(2002 Jul 03), pp. 3-5-5. [10.1016/S0014-5793(02)02881-8]
Does chloroquine really act through oxidative stress?
N. Basilico;S. Parapini;D. Taramelli
2002
Abstract
To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO(2) and 93% N(2). Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested.
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