Background: The clinical use of cyclosporine as an immunosuppressive agent enhanced long-term survival in transplant recipients at the expense of a high incidence of induced hypertension. Altered neurovegetative (autonomic) cardiovascular control is suspected as a mechanism of this form of hypertension. Methods: Spectral analysis of systolic arterial pressure and R- R interval variability (electrocardiographic recordings) were performed, and the index α of baroreflex gain was computed in four groups of subjects matched for age: 13 orthotopic heart transplant recipients; 13 solid organ transplant recipients; 13 patients with essential hypertension; and 18 control subjects with normal blood pressure. All but the control subjects were treated with similar dihydropyridine calcium entry blockers. Heart and solid organ transplant recipients also received cyclosporine. Results: R-R variance was lowest in the heart transplant recipients. The spectral profile of R-R interval was suggestive of sympathetic predominance in the patients withhypertension, but not in the solid organ transplant recipients or the control subjects. Systolic blood pressure variability and low frequency component (a marker of sympathetic vasomotor modulation) were similar in the four groups. The index α was 1.8 ± 2.2 in heart transplant recipients, 11.7 ± 6.6 in solid organ transplant recipients, 7.3 ± 3.6 in patients with hypertension, and 13.5 ± 6.4 msec/mm Hg in control subjects (p = 0.0001). Conclusions: These data indicate that (1) cyclosporine-induced hypertension in heart transplant recipients is associated with a loss of baroreflex function as a result of cardiac denervation-related uncoupling; (2) compared with patients with hypertension, organ transplant recipients with hypertension demonstrated a maintained baroreflex function as indicated by a lack of reduction of the index α; (3) baroreflex heart rate control in dihydropyridine-treated cyclosporine-induced hypertension is well maintained.

Ciclosporine induced hypertension evidence for mainained baroreflex circulatory control / D. Lucini, R.V. Milani, H.O. Ventura, M.R. Mehra, F.H. Messerli, J.P. Murgo, F. Regenstein, B. Copley, A. Malliani, M. Pagani. - In: THE JOURNAL OF HEART AND LUNG TRANSPLANTATION. - ISSN 1053-2498. - 16:6(1997), pp. 615-620.

Ciclosporine induced hypertension evidence for mainained baroreflex circulatory control

D. Lucini
Primo
;
A. Malliani
Penultimo
;
M. Pagani
Ultimo
1997

Abstract

Background: The clinical use of cyclosporine as an immunosuppressive agent enhanced long-term survival in transplant recipients at the expense of a high incidence of induced hypertension. Altered neurovegetative (autonomic) cardiovascular control is suspected as a mechanism of this form of hypertension. Methods: Spectral analysis of systolic arterial pressure and R- R interval variability (electrocardiographic recordings) were performed, and the index α of baroreflex gain was computed in four groups of subjects matched for age: 13 orthotopic heart transplant recipients; 13 solid organ transplant recipients; 13 patients with essential hypertension; and 18 control subjects with normal blood pressure. All but the control subjects were treated with similar dihydropyridine calcium entry blockers. Heart and solid organ transplant recipients also received cyclosporine. Results: R-R variance was lowest in the heart transplant recipients. The spectral profile of R-R interval was suggestive of sympathetic predominance in the patients withhypertension, but not in the solid organ transplant recipients or the control subjects. Systolic blood pressure variability and low frequency component (a marker of sympathetic vasomotor modulation) were similar in the four groups. The index α was 1.8 ± 2.2 in heart transplant recipients, 11.7 ± 6.6 in solid organ transplant recipients, 7.3 ± 3.6 in patients with hypertension, and 13.5 ± 6.4 msec/mm Hg in control subjects (p = 0.0001). Conclusions: These data indicate that (1) cyclosporine-induced hypertension in heart transplant recipients is associated with a loss of baroreflex function as a result of cardiac denervation-related uncoupling; (2) compared with patients with hypertension, organ transplant recipients with hypertension demonstrated a maintained baroreflex function as indicated by a lack of reduction of the index α; (3) baroreflex heart rate control in dihydropyridine-treated cyclosporine-induced hypertension is well maintained.
Settore MED/09 - Medicina Interna
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182685
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 14
social impact