Abstract: also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Here we report that Tir8 has a unique pattern of expression, which includes mucosal tissues and dendritic cells (DC). Tir8-deficient DC showed increased cytokine production in response to TLR agonists (lipopolysaccharide, CpG oligodeoxynucleotides). Tir8-deficient mice had normal susceptibility to systemic lipopolysaccharide toxicity and to i.p. or s.c. inflammation. However, Tir8-deficient mice were more susceptible to intestinal inflammation. Thus, TIR8 represents a negative pathway of regulation of the IL-1 receptor/TLR system, expressed in epithelial cells and DC, crucial for tuning inflammation in the gastrointestinal tract.
Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family / C. Garlanda, F. Riva, N. Polentarutti, C. Buracchi, M. Sironi, M. De Bortoli, M. Muzio, R. Bergottini, E. Scanziani, A. Vecchi, E. Hirsch, A. Mantovani. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 101:10(2004 Mar), pp. 3522-3526.
|Titolo:||Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family|
RIVA, FEDERICA (Secondo)
MANTOVANI, ALBERTO (Ultimo)
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
Settore VET/05 - Malattie Infettive degli Animali Domestici
Settore MED/04 - Patologia Generale
|Data di pubblicazione:||mar-2004|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1073/pnas.0308680101|
|Appare nelle tipologie:||01 - Articolo su periodico|