The effects of histamine and amodiaquine (a drug known to inhibit histamine-N-methyltransferase) on pulsatile growth hormone (GH) secretion were determined in unanaesthetized male rats. Intracerebroventricular (i.c.v.) administration of histamine (0.01, 0.05, 0.1 mumol/rat) caused a dose-related suppression of spontaneous pulses of rat GH (rGH) secretion. Amodiaquine (0.16 mumol/rat i.c.v.) also inhibited the pulses, but to a lesser degree. The results, which show the inhibitory effects of both exogenous histamine and increased levels of endogenous histamine on pulsatile rGH secretion, support the hypothesis that the histaminergic system also plays a role in physiological CNS control of rGH secretion.
Influence of brain histaminergic system on episodic growth hormone secretion in the rat / C. Netti, F. Guidobono, V. R. Olgiati, V. Sibilia, F. Pagani, A. Pecile. - In: NEUROENDOCRINOLOGY. - ISSN 0028-3835. - 35:1(1982), pp. 43-47.
Titolo: | Influence of brain histaminergic system on episodic growth hormone secretion in the rat | |
Autori: | GUIDOBONO CAVALCHINI, FRANCESCA (Secondo) PAGANI, FRANCESCA (Penultimo) | |
Parole Chiave: | Rats, Inbred Strains; Rats; Animals; Amodiaquine; Brain; Receptors, Histamine; Male; Histamine; Growth Hormone | |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia | |
Data di pubblicazione: | 1982 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1159/000123353 | |
Appare nelle tipologie: | 01 - Articolo su periodico |