Astragalus spp. (Leguminosae) represent a valid rural crop of ecological importance in many countries, and some species serve as foodstuffs and pharmaceutical emulsifiers. Astragalus species are used in Chinese traditional medicine as antiperspirant, antihypertensive, antidiabetic, diuretic and tonic. The pharmacologically active constituents of theseAstragalus are of two different types, polysaccharides and saponins, and the most interesting pharmacological properties are hepatoprotective, immunostimulant and antiviral. Astragalus species are a source of cycloartane type saponins, derived from cycloartenol by oxidation at C-6, C-16, C-20, C-23, C-24, followed by possible ring closures with the formation of a 20,24-epoxide (cycloastragenol or cyclogalegenin) or a 20,25-epoxide, or a 16,24-20,24- diepoxide (cycloalpigenin), or a 16,23-16,24-diepoxide (cycloorbigenin B). Approximatively 100 saponins mainly derivatives of the 20(R),24(S) form of cycloastragenol [3β,6α,25-tetrahydroxy-20(R),24(S)-epoxy-9,19-cyclolanostane], (astragalosides or astraversianins), and more rarely of the 20(S), 24(R) form (cyclogalegenin), have been isolated. Some species also contain trihydroxyolean-12-ene saponins. Details on the isolation, purification and structural elucidation, along with recent results on the pharmacological properties of Astragalus cycloartane and oleanane saponins, will be discussed.

Cycloartane and Oleanane Saponins from Astragalus sp / 58) L. Verotta,* N.A. El-Sebakhy - In: Studies in Natural Products Chemistry. XXV / [a cura di] Atta-ur-Rahman. - Amsterdam : Elsevier Science Publishers, 2001. - ISBN 0-08-044001-0. - pp. 179-234 [10.1016/S1572-5995(01)80008-9]

Cycloartane and Oleanane Saponins from Astragalus sp

5. Verotta
Primo
;
2001

Abstract

Astragalus spp. (Leguminosae) represent a valid rural crop of ecological importance in many countries, and some species serve as foodstuffs and pharmaceutical emulsifiers. Astragalus species are used in Chinese traditional medicine as antiperspirant, antihypertensive, antidiabetic, diuretic and tonic. The pharmacologically active constituents of theseAstragalus are of two different types, polysaccharides and saponins, and the most interesting pharmacological properties are hepatoprotective, immunostimulant and antiviral. Astragalus species are a source of cycloartane type saponins, derived from cycloartenol by oxidation at C-6, C-16, C-20, C-23, C-24, followed by possible ring closures with the formation of a 20,24-epoxide (cycloastragenol or cyclogalegenin) or a 20,25-epoxide, or a 16,24-20,24- diepoxide (cycloalpigenin), or a 16,23-16,24-diepoxide (cycloorbigenin B). Approximatively 100 saponins mainly derivatives of the 20(R),24(S) form of cycloastragenol [3β,6α,25-tetrahydroxy-20(R),24(S)-epoxy-9,19-cyclolanostane], (astragalosides or astraversianins), and more rarely of the 20(S), 24(R) form (cyclogalegenin), have been isolated. Some species also contain trihydroxyolean-12-ene saponins. Details on the isolation, purification and structural elucidation, along with recent results on the pharmacological properties of Astragalus cycloartane and oleanane saponins, will be discussed.
Settore CHIM/06 - Chimica Organica
Book Part (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182439
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 34
  • ???jsp.display-item.citation.isi??? ND
social impact