We investigated whether inhibition of brain histamine (HA) synthesis by alpha-fluoromethylhistidine (alpha-FMH) can influence basal or stimulated prolactin (PRL) release in male rats. alpha-FMH was administered either into the carotid (i.a., 20 and 100 mg/kg) or intracerebroventricularly (i.c.v., 200 micrograms/rat) into freely moving rats with indwelling catheters. Plasma PRL levels were measured 90, 120, 180 min later. Both i.a. and i.c.v. administration of alpha-FMH significantly inhibited basal PRL secretion at 120 and 180 min. When PRL secretion was stimulated by exposing rats to restraint stress, alpha-FMH administered 3 h before the stress (20 and 100 mg/kg, i.a.; 200 micrograms/rat, i.c.v.) was able to prevent the PRL surges at 10 and 20 min after stress. These results suggest that endogenous brain HA has a facilitatory role in the control of PRL secretion in rats.

Involvement of brain histamine in basal and stress-induced release of prolactin in the rat / C. Netti, F. Guidobono, V. Sibilia, I. Villa, E. Cazzamalli, A. Pecile. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - 20:3-4(1987 Apr), pp. 236-238.

Involvement of brain histamine in basal and stress-induced release of prolactin in the rat

F. Guidobono
Secondo
;
V. Sibilia;
1987

Abstract

We investigated whether inhibition of brain histamine (HA) synthesis by alpha-fluoromethylhistidine (alpha-FMH) can influence basal or stimulated prolactin (PRL) release in male rats. alpha-FMH was administered either into the carotid (i.a., 20 and 100 mg/kg) or intracerebroventricularly (i.c.v., 200 micrograms/rat) into freely moving rats with indwelling catheters. Plasma PRL levels were measured 90, 120, 180 min later. Both i.a. and i.c.v. administration of alpha-FMH significantly inhibited basal PRL secretion at 120 and 180 min. When PRL secretion was stimulated by exposing rats to restraint stress, alpha-FMH administered 3 h before the stress (20 and 100 mg/kg, i.a.; 200 micrograms/rat, i.c.v.) was able to prevent the PRL surges at 10 and 20 min after stress. These results suggest that endogenous brain HA has a facilitatory role in the control of PRL secretion in rats.
Animals; Injections, Intra-Arterial; Pituitary Gland, Anterior; Brain; Histamine; Injections, Intraventricular; Carotid Arteries; Prolactin; Rats; Rats, Inbred Strains; Methylhistidines; Male; Stress, Physiological
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182410
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