Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither β-casomorphins (βCMS), which are opioid peptides derived from the enzymatic digestion of milk protein (β-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.

Ultrasonic vocalization in rat pups as a marker of behavioral development: An investigation of the effects of drugs influencing brain opioid system / V. Cuomo, R. Cagiano, M.A. De Salvia, p. Restani, R. Galimberti, S. Colonna, G. Racagni, C.L. Galli. - In: NEUROTOXICOLOGY AND TERATOLOGY. - ISSN 0892-0362. - 10:5(1988), pp. 465-469.

Ultrasonic vocalization in rat pups as a marker of behavioral development: An investigation of the effects of drugs influencing brain opioid system

p. Restani;S. Colonna;G. Racagni
Penultimo
;
C.L. Galli
Ultimo
1988

Abstract

Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither β-casomorphins (βCMS), which are opioid peptides derived from the enzymatic digestion of milk protein (β-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/182331
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