Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither β-casomorphins (βCMS), which are opioid peptides derived from the enzymatic digestion of milk protein (β-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.
|Titolo:||Ultrasonic vocalization in rat pups as a marker of behavioral development: An investigation of the effects of drugs influencing brain opioid system|
RACAGNI, GIORGIO ANGELO (Penultimo)
GALLI, CORRADO LODOVICO (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1988|
|Digital Object Identifier (DOI):||10.1016/0892-0362(88)90009-8|
|Appare nelle tipologie:||01 - Articolo su periodico|