Metronidazole benzoate, an antiprotozoal drug, forms a 1:1 (mol:mol) inclusion compound with gammacyclodextrin. Phase-solubility analysis, differential scanning calorimetry, X-ray diffraction on powder, and infrared spectra were used in order to characterize the inclusion compound both in solution and in the solid state. The stability of the drug to alkaline hydrolysis was improved in aqueous solutions of gamma-cyclodextrin.
Preparation and characterization of metronidazole benzoate-gammacyclodextrin inclusion compound / F. Giordano, G. Bruni, I.A. Hadi, M. Kata, A. Gazzaniga, G. Bettinetti. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 131:4(1992), pp. 150-156.
Titolo: | Preparation and characterization of metronidazole benzoate-gammacyclodextrin inclusion compound |
Autori: | GAZZANIGA, ANDREA (Penultimo) |
Parole Chiave: | γ-cyclodextrin; FTIR; inclusion compound; metronidazole benzoate; thermal analysis; X-ray spectra |
Settore Scientifico Disciplinare: | Settore CHIM/09 - Farmaceutico Tecnologico Applicativo |
Data di pubblicazione: | 1992 |
Rivista: | |
Tipologia: | Article (author) |
Appare nelle tipologie: | 01 - Articolo su periodico |