The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have generally been attributed to their hypocholesterolaemic properties. However, as mevalonate and other intermediates of cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important cell functions, effects other than cholesterol reduction may explain the pharmacological properties of statins. In the present review, we discuss the current knowledge on the nonlipid-related effects of statins, with a special emphasis on their potential benefits in different diseases, such as atherosclerosis and cancer. The mechanism(s) responsible for their favourable properties are also reviewed.
Non-lipid-related effects of statins / S. Bellosta, N. Ferri, F. Bernini, R. Paoletti, A. Corsini. - In: ANNALS OF MEDICINE. - ISSN 0785-3890. - 32:3(2000), pp. 164-176.
|Titolo:||Non-lipid-related effects of statins|
BELLOSTA, STEFANO (Primo)
FERRI, NICOLA (Secondo)
PAOLETTI, RODOLFO (Penultimo)
CORSINI, ALBERTO (Ultimo)
|Parole Chiave:||arterial smooth muscle cell proliferation; atherosclerosis; cancer; cholesterol accumulation; endothelial function; inflammation; macrophages; migration; statins; thrombosis|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2000|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/07853890008998823|
|Appare nelle tipologie:||01 - Articolo su periodico|