The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have generally been attributed to their hypocholesterolaemic properties. However, as mevalonate and other intermediates of cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important cell functions, effects other than cholesterol reduction may explain the pharmacological properties of statins. In the present review, we discuss the current knowledge on the nonlipid-related effects of statins, with a special emphasis on their potential benefits in different diseases, such as atherosclerosis and cancer. The mechanism(s) responsible for their favourable properties are also reviewed.

Non-lipid-related effects of statins / S. Bellosta, N. Ferri, F. Bernini, R. Paoletti, A. Corsini. - In: ANNALS OF MEDICINE. - ISSN 0785-3890. - 32:3(2000), pp. 164-176.

Non-lipid-related effects of statins

S. Bellosta
Primo
;
N. Ferri
Secondo
;
R. Paoletti
Penultimo
;
A. Corsini
Ultimo
2000

Abstract

The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have generally been attributed to their hypocholesterolaemic properties. However, as mevalonate and other intermediates of cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important cell functions, effects other than cholesterol reduction may explain the pharmacological properties of statins. In the present review, we discuss the current knowledge on the nonlipid-related effects of statins, with a special emphasis on their potential benefits in different diseases, such as atherosclerosis and cancer. The mechanism(s) responsible for their favourable properties are also reviewed.
arterial smooth muscle cell proliferation; atherosclerosis; cancer; cholesterol accumulation; endothelial function; inflammation; macrophages; migration; statins; thrombosis
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/182131
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