Solubility and phase-solubility studies were performed on khellin, a member of the psoralens' family with interesting antivitiligo properties, in order to achieve a correct formulation for topical dosage forms. γ- cyclodextrin, hydroxypropyl-β-cyclodextrin and dimethyl-β-cyclodextrin allowed a significant enhancement of khellin's solubility in aqueous media, especially when used in combination. Water-organic solvents systems (2- propanol and propylene glycol) were used to prepare gels containing significant amounts (0.5, 1% by weight) of the active ingredient. Permeation of khellin from topical formulations was also investigated.

Preformulation studies and formulation strategies on khellin, an old/new antivitiligo agent: Interaction with cyclodextrins, solubility in mixed solvent systems and permeation through artificial membranes / F. Giordano, M. Rillosi, P. Benelli, M.E. Sangalli, G.P. Bettinetti, G. Orecchia, A. Gazzaniga. - In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - ISSN 0939-6411. - 40:4(1994), pp. 232-236.

Preformulation studies and formulation strategies on khellin, an old/new antivitiligo agent: Interaction with cyclodextrins, solubility in mixed solvent systems and permeation through artificial membranes

M.E. Sangalli;A. Gazzaniga
Ultimo
1994

Abstract

Solubility and phase-solubility studies were performed on khellin, a member of the psoralens' family with interesting antivitiligo properties, in order to achieve a correct formulation for topical dosage forms. γ- cyclodextrin, hydroxypropyl-β-cyclodextrin and dimethyl-β-cyclodextrin allowed a significant enhancement of khellin's solubility in aqueous media, especially when used in combination. Water-organic solvents systems (2- propanol and propylene glycol) were used to prepare gels containing significant amounts (0.5, 1% by weight) of the active ingredient. Permeation of khellin from topical formulations was also investigated.
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181836
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