A delayed release system, based on the coating of cores with hydrophilic derivatives of cellulose (hydroxypropylmethylcellulose) and useful for controlling time and/or site of delivery, is described. The overall mechanism responsible for the burst in release profile after a predetermined lag- phase, based on the water/polymer interaction, is outlined. In vitro release data from systems prepared by press-coating or spray-coating of fast disintegrating cores containing model drugs (indomethacin or verapamil · HCl) are reported.
Oral chronotopic® drug delivery systems: Achievement of time and/or site specificity / A. Gazzaniga, M.E. Sangalli, F. Giordano. - In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - ISSN 0939-6411. - 40:4(1994), pp. 246-250.
Oral chronotopic® drug delivery systems: Achievement of time and/or site specificity
A. GazzanigaPrimo
;M.E. SangalliSecondo
;
1994
Abstract
A delayed release system, based on the coating of cores with hydrophilic derivatives of cellulose (hydroxypropylmethylcellulose) and useful for controlling time and/or site of delivery, is described. The overall mechanism responsible for the burst in release profile after a predetermined lag- phase, based on the water/polymer interaction, is outlined. In vitro release data from systems prepared by press-coating or spray-coating of fast disintegrating cores containing model drugs (indomethacin or verapamil · HCl) are reported.
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