The swelling and dissolution behavior of pharmaceutical systems containing a drug and a polymer can be analyzed by a mathematical model which predicts the drug released and the gel layer thickness as a function of time. It is possible to approximate the values of several of the physicochemical parameters of this model in order to obtain an order-of-magnitude analysis of the tablet dissolution process. Selected experimental results of tablet dissolution and drug release are analyzed and conclusions are made about the importance of the drug and polymer content and solubility in the release behavior.

Drug/polymer matrix swelling and dissolution / R. S. Harland, A. Gazzaniga, M. E. Sangalli, P. Colombo, N. A. Peppas. - In: PHARMACEUTICAL RESEARCH. - ISSN 0724-8741. - 5:8(1988 Aug), pp. 488-494. [10.1023/A:1015913207052]

Drug/polymer matrix swelling and dissolution

A. Gazzaniga
Secondo
;
M.E. Sangalli;
1988

Abstract

The swelling and dissolution behavior of pharmaceutical systems containing a drug and a polymer can be analyzed by a mathematical model which predicts the drug released and the gel layer thickness as a function of time. It is possible to approximate the values of several of the physicochemical parameters of this model in order to obtain an order-of-magnitude analysis of the tablet dissolution process. Selected experimental results of tablet dissolution and drug release are analyzed and conclusions are made about the importance of the drug and polymer content and solubility in the release behavior.
Polyvinyls; Solubility; Physicochemical Phenomena; Delayed-Action Preparations; Chemistry, Physical; Chemistry, Pharmaceutical; Tablets; Spectrophotometry, Ultraviolet; Diffusion; Polymers; Pharmaceutical Preparations
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181629
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