Binary systems of naproxen with statistically-alkylated ßcyclodextrins (methyl, hydroxyethyl and hydroxypropyl derivatives) were investigated for both solid phase characterization (differential scanning calorimetry, X-ray powder diffraction) and dissolution properties (dispersed amount and rotating disc methods). Kneading, coevaporation and colyophilization of the 1:1 (mol/mol) naproxen/methyl ßcyclodextrin combination, as well as colyophilization of analogous combinations of naproxen with hydroxyethyl and hydroxypropyl ßcyclodextrin, led to amorphous products with higher dissolution rates than the corresponding physical mixtures. A conversion of crystalline to amorphous naproxen was also observed by heating the physical mixtures at about 393 K. The amorphous statistically-alkylated ßcyclodextrins, in particular methyl ßcyclodextrin, can be employed as amorphizing agents for crystalline naproxen.

Thermal behaviour and dissolution properties of naproxen in combinations with chemically modified ß-Cyclodextrins / G. Bettinetti, A. Gazzaniga, P. Mura, F. Giordano, M. Setti. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - 18:1(1992), pp. 39-53.

Thermal behaviour and dissolution properties of naproxen in combinations with chemically modified ß-Cyclodextrins

A. Gazzaniga
Secondo
;
1992

Abstract

Binary systems of naproxen with statistically-alkylated ßcyclodextrins (methyl, hydroxyethyl and hydroxypropyl derivatives) were investigated for both solid phase characterization (differential scanning calorimetry, X-ray powder diffraction) and dissolution properties (dispersed amount and rotating disc methods). Kneading, coevaporation and colyophilization of the 1:1 (mol/mol) naproxen/methyl ßcyclodextrin combination, as well as colyophilization of analogous combinations of naproxen with hydroxyethyl and hydroxypropyl ßcyclodextrin, led to amorphous products with higher dissolution rates than the corresponding physical mixtures. A conversion of crystalline to amorphous naproxen was also observed by heating the physical mixtures at about 393 K. The amorphous statistically-alkylated ßcyclodextrins, in particular methyl ßcyclodextrin, can be employed as amorphizing agents for crystalline naproxen.
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181556
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 53
  • ???jsp.display-item.citation.isi??? 47
social impact