The effects of intracerebroventricular injection of histamine H2-receptor agonists (4-methylhistamine, 4-MeH; dimaprit, DIM), H2-antagonists (cimetidine, CIM; ranitidine, RAN; famotidine, FAM) and of the DIM chemical analogue SK&F 91487 on hot-plate latency in rats were examined. Both DIM (0.4-0.8 mumol/rat) and 4-MeH (0.4-0.8 mumol/rat) significantly enhanced the pain threshold, whereas SF&F 91487 (0.8 mumol/rat) had no effect, indicating that DIM antinociception is specifically due to its activity on histamine (HA) receptors. The H2-antagonists CIM (0.8 mumol/rat) and RAN (0.6 mumol/rat) also enhanced the pain threshold, while FAM (0.03 mumol/rat) did not modify pain latency. When injected before 4-MeH, FAM reduced the antinociceptive effect of 4-MeH. These findings suggest that the antinociceptive activity of CIM and RAN is not related to specific blockade of H2-receptors and that the activation of HA-H2-receptors is inhibitory to nociception.
Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat / C. Netti, F. Guidobono, V. Sibilia, I. Villa, E. Cazzamalli, A. Pecile. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - 23:3-4(1988 Apr), pp. 247-249.
|Titolo:||Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat|
GUIDOBONO CAVALCHINI, FRANCESCA (Secondo)
|Parole Chiave:||Rats, Inbred Strains; Rats; Dimaprit; Animals; Methylhistamines; Thiourea; Nociceptors; Receptors, Histamine H2; Male; Histamine H2 Antagonists|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-1988|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF02142554|
|Appare nelle tipologie:||01 - Articolo su periodico|