27 male N.Z.W. rabbits (1953 +/- 32 g initial live weight) were housed in individual metabolic cages in a controlled environment maintainedat a temperature of 18-degrees-C, illuminated between 8 AM and 8 PM. The animals were divided into 3 homogenous groups fed ad libitum (from6 PM to 9 AM) diets containing different levels of clenbuterol (CB) (C: control diet, T-0.5: control diet plus 0.5 mg/kg CB, T-1: control diet plus 1 mg/kg CB). Two N-balance trials were performed:days 4 through 8 and days 27 through 31 from the beginning of administration of experimental diet. CB treatment significantly improved final live weight (about + 8.9%), with no dose-effect. Treatment did not affect feed intake, while a better feed efficiency was observed for groups receiving CB. During the N-balance study no treatment-effects wereobserved on N intake nor on fecal N. The beta-adrenergic agonist increased N-retained (P < 0.01) and reduced N-urinary excretion (P < 0.01). The effects of CB treatment on reducing urea, OH-proline and alpha-amino-N excretion were initially greater. Our data indicate that the beta-agonist reduces amino acid oxidation, collagen protein degradation and spares amino acids, thus contributing to enhanced efficiency of N deposition. Creatinine-N excretion was significantly increased only during second period of N-balance (P < 0.001). Treatment with CB significantly improved the dressing percentage. The semimembranosus muscle was significantly heavier in the treated group (T-1) than in the controls, due to muscle hypertrophy. The muscle hypertrophy caused by CB included a general effect on the cross-sectional area of all fibre types and a transformation of fibre types, especially type IIA to IIB.

Effects of clenbuterol on rabbit growth, nitrogen balance and skeletal muscle fibres / C. Corino, F. Mascarello, F. Rosi. - In: JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION. - ISSN 0931-2439. - 69:1-5(1993), pp. 267-277.

Effects of clenbuterol on rabbit growth, nitrogen balance and skeletal muscle fibres

C. Corino
Primo
;
F. Rosi
Ultimo
1993

Abstract

27 male N.Z.W. rabbits (1953 +/- 32 g initial live weight) were housed in individual metabolic cages in a controlled environment maintainedat a temperature of 18-degrees-C, illuminated between 8 AM and 8 PM. The animals were divided into 3 homogenous groups fed ad libitum (from6 PM to 9 AM) diets containing different levels of clenbuterol (CB) (C: control diet, T-0.5: control diet plus 0.5 mg/kg CB, T-1: control diet plus 1 mg/kg CB). Two N-balance trials were performed:days 4 through 8 and days 27 through 31 from the beginning of administration of experimental diet. CB treatment significantly improved final live weight (about + 8.9%), with no dose-effect. Treatment did not affect feed intake, while a better feed efficiency was observed for groups receiving CB. During the N-balance study no treatment-effects wereobserved on N intake nor on fecal N. The beta-adrenergic agonist increased N-retained (P < 0.01) and reduced N-urinary excretion (P < 0.01). The effects of CB treatment on reducing urea, OH-proline and alpha-amino-N excretion were initially greater. Our data indicate that the beta-agonist reduces amino acid oxidation, collagen protein degradation and spares amino acids, thus contributing to enhanced efficiency of N deposition. Creatinine-N excretion was significantly increased only during second period of N-balance (P < 0.001). Treatment with CB significantly improved the dressing percentage. The semimembranosus muscle was significantly heavier in the treated group (T-1) than in the controls, due to muscle hypertrophy. The muscle hypertrophy caused by CB included a general effect on the cross-sectional area of all fibre types and a transformation of fibre types, especially type IIA to IIB.
beta-adrenergic agonist ; skeletal fiber ; rabbit growth ; nitrogen balance ; OH-proline
Settore AGR/18 - Nutrizione e Alimentazione Animale
Settore VET/01 - Anatomia degli Animali Domestici
http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0396.1993.tb00814.x/abstract
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/179620
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