Eicosanoids are biologically active lipids in both physiologic and pathophysiologic situations. These mediators rapidly generate at sites of inflammation and act through specific receptors that following the generation of a signal transduction cascade, lead to coordinated cellular responses to specific stimuli. Prostanoids, that is, prostaglandins and thromboxane A(2) , are active products of the cyclooxygenase pathway, while leukotrienes and lipoxins derive from the lipoxygenase pathway. In addition, a complex family of prostaglandin isomers called isoprostanes is derived as free-radical products of oxidative metabolism. While there is a wide consensus on the importance of the balance between proaggregating (thromboxane A(2) ) and antiaggregating (prostacyclin) cyclooxygenase products in cardiovascular homeostasis, an increasing body of evidence suggests a key role also for other eicosanoids generated by lipoxygenases, epoxygenases, and nonenzymatic pathways in cardiovascular diseases. This intricate network of lipid mediators is unique considering that from a single precursor, arachidonic acid, may derive an array of bioproducts that interact within each other synergizing or, more often, behaving as functional antagonists.
Eicosanoids and Their Drugs in Cardiovascular Diseases : Focus on Atherosclerosis and Stroke / V. Capra, M. Bäck, S.S. Barbieri, M. Camera, E. Tremoli, G.E. Rovati. - In: MEDICINAL RESEARCH REVIEWS. - ISSN 0198-6325. - 33:2(2013 Mar), pp. 364-438.
|Titolo:||Eicosanoids and Their Drugs in Cardiovascular Diseases : Focus on Atherosclerosis and Stroke|
CAPRA, VALERIE CAROLINE (Primo)
TREMOLI, ELENA (Penultimo)
ROVATI, GIANENRICO (Ultimo)
|Parole Chiave:||Cardiovascular disease; Eicosanoids; Leukotrienes; Lipoxins; Prostanoids|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||mar-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/med.21251|
|Appare nelle tipologie:||01 - Articolo su periodico|