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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishE-cadherin is best characterized as adherens junction protein, which through homotypic interactions contributes to the maintenance of the epithelial barrier function. In epithelial cells, the cytoplasmic tail of E-cadherin forms a dynamic complex with catenins and regulates several intracellular signal transduction pathways, including Wnt/β-catenin, PI3K/Akt, Rho GTPase, and NF-κB signaling. Recent progress uncovered a novel and critical role for this adhesion molecule in mononuclear phagocyte functions. E-cadherin regulates the maturation and migration of Langerhans cells, and its ligation prevents the induction of a tolerogenic state in bone marrow-derived dendritic cells (DCs). In this respect, the functionality of β-catenin could be instrumental in determining the balance between immunogenicity and tolerogenicity of DCs in vitro and in vivo. Fusion of alternatively activated macrophages and osteoclasts is also E-cadherin-dependent. In addition, the E-cadherin ligands CD103 and KLRG1 are expressed on DC-, T-, and NK-cell subsets and contribute to their interaction with E-cadherin-expressing DCs and macrophages. Here we discuss the regulation, function, and implications of E-cadherin expression in these central orchestrators of the immune system.
Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs / J. Van den Bossche, B. Malissen, A. Mantovani, P. De Baetselier, J. A. Van Ginderachter. - In: BLOOD. - ISSN 0006-4971. - 119:7(2012 Feb 16), pp. 1623-1633.
| Titolo: | Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs |
| Autori: | |
| Parole Chiave: | Macrophages ; Animals ; Dendritic Cells ; Cell Lineage ; Humans ; beta Catenin ; Cell Differentiation ; Cadherins ; Models, Biological ; Multiprotein Complexes ; Monocytes ; Signal Transduction ; Immune System |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
| Data di pubblicazione: | 16-feb-2012 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1182/blood-2011-10-384289 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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