The detailed investigation of Astralagus trigonus DC roots, led to the isolation of a new cycloartan-3 beta, 16 beta diglucoside, whose structure was elucidated by extensive use of 1D- and 2D- high field (600 MHz) NMR techniques. The NaBH4 reduction of the natural 6-ore 3 beta, 16 beta diglucoside, previously isolated from the same plant, afforded the 6-epi-derivative of the new compound. The conformational preference of both these compounds has been investigated by high field H-1 NMR spectroscopy and molecular modeling techniques.
A cycloartane triterpene 3β, 16β diglucoside from Astragalus trigonus and its non natural 6-hydroxy epimer / L. Verotta, F. Orsini, M. Tato, N. El-Sebakhy, S. Toaima. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - 49:3(1998 Oct), pp. 845-852.
A cycloartane triterpene 3β, 16β diglucoside from Astragalus trigonus and its non natural 6-hydroxy epimer
L. VerottaPrimo
;F. OrsiniSecondo
;
1998
Abstract
The detailed investigation of Astralagus trigonus DC roots, led to the isolation of a new cycloartan-3 beta, 16 beta diglucoside, whose structure was elucidated by extensive use of 1D- and 2D- high field (600 MHz) NMR techniques. The NaBH4 reduction of the natural 6-ore 3 beta, 16 beta diglucoside, previously isolated from the same plant, afforded the 6-epi-derivative of the new compound. The conformational preference of both these compounds has been investigated by high field H-1 NMR spectroscopy and molecular modeling techniques.
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