The long-term impact of pegylated-interferon plus ribavirin (Peg-IFN-RBV) treatment outcome on CD4 T cell course in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is unknown. The aim of this study was to investigate the impact of HCV-RNA clearance by standard anti-HCV therapy on long-term CD4 cells recovery in HIV/HCV patients on successful combined antiretroviral therapy (cART). We retrospectively enrolled HIV/HCV-coinfected patients on stable cART, treated with Peg-IFN-RBV between 2005 and 2009. CD4(+) T cell counts were registered at baseline (pre-Peg-IFN-RBV), after 6, 12, and 24 months of follow-up from therapy discontinuation. Multiple linear regression analysis was performed to identify independent predictors of CD4(+) T cell change following the anti-HCV treatment outcome. Of the 116 patients enrolled, 54 (46.6%) reached a sustained virological response (SVR) and 62 (53.4%) did not. Throughout a median follow-up of 24 months, the SVR group showed a mean annual increase in CD4(+) T cell from baseline of 84 cells/μl at 1 year and of a further 38 cells/μl within the second year (p=0.01, 0.001, respectively). A nonsignificant mean increase of 77 cells/μl occurred in the non-SVR group within month 24 (p=0.06). Variables associated with greater CD4 gains were higher nadir and lower pre-interferon CD4 counts, and lower body mass index (BMI). The achievement of SVR was not significantly associated with the change in CD4(+) count. The clearance of HCV replication did not affect the CD4(+) changes after Peg-IFN-RBV therapy in coinfected patients on efficient cART. Liver fibrosis and higher BMI were negative determinants of immune recovery.
Impact of Hepatitis C Viral Clearance on CD4(+) T-Lymphocyte Course in HIV/HCV-Coinfected Patients Treated with Pegylated Interferon Plus Ribavirin / L. Milazzo, A. Foschi, C. Mazzali, A. Viola, A. Ridolfo, M. Galli, S. Antinori. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 28:9(2012 Sep), pp. 789-793.
|Titolo:||Impact of Hepatitis C Viral Clearance on CD4(+) T-Lymphocyte Course in HIV/HCV-Coinfected Patients Treated with Pegylated Interferon Plus Ribavirin|
FOSCHI, ANTONELLA (Secondo)
GALLI, MASSIMO (Penultimo)
ANTINORI, SPINELLO (Ultimo)
|Parole Chiave:||hepatitis C ; HIV ; viral clearance ; pegylated interferon|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
Settore MED/01 - Statistica Medica
|Data di pubblicazione:||set-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1089/aid.2011.0323|
|Appare nelle tipologie:||01 - Articolo su periodico|