The possibility of using high viscosity grades of hydroxypropylmethylcellulose (HPMC) as a film forming agent in a conventional coating process has been investigated. Ethanol/water mixtures having different weight ratios (5 to 18) and containing up to 5 % of HPMC revealed to be suitable. The influence of some formulation additives (talc, PVP and plasticizers) on both the overall coating process and the in-vitro release profiles of ketoprofen containing coated tablets was also investigated and discussed.
High-Viscosity HPMC as a Film-Coating Agent / G. Maffione, P. Iamartino, G. Guglielmini, A. Gazzaniga. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - 19:16(1993), pp. 2043-2053.
|Titolo:||High-Viscosity HPMC as a Film-Coating Agent|
GAZZANIGA, ANDREA (Ultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Data di pubblicazione:||1993|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/03639049309069340|
|Appare nelle tipologie:||01 - Articolo su periodico|