Forty-three patients were entered in an uncontrolled study designed to evaluate extracorporeal membrane lung support in severe acute respiratory failure of parenchymal origin. Most of the metabolic carbon dioxide production was cleared through a low-flow venovenous bypass. To avoid lung injury from conventional mechanical ventilation, the lungs were kept "at rest" (three to five breaths per minute) at a low peak airway pressure of 35 to 45 cm H2O (3.4 to 4.4 kPa). The entry criteria were based on gas exchange under standard ventilatory conditions (expected mortality rate, greater than 90%). Lung function improved in thirty-one patients (72.8%), and 21 patients (48.8%) eventually survived. The mean time on bypass for the survivors was 5.4 +/- 3.5 days. Improvement in lung function, when present, always occurred within 48 hours. Blood loss averaged 1800 +/- 850 mL/d. No major technical accidents occurred in more than 8000 hours of perfusion. Extracorporeal carbon dioxide removal with low-frequency ventilation proved a safe technique, and we suggest it as a valuable tool and an alternative to treating severe acute respiratory failure by conventional means.
Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure / L. Gattinoni, A. Pesenti, D. Mascheroni, R. Marcolin, R. Fumagalli, F. Rossi, G. Iapichino, G. Romagnoli, L. Uziel, A. Agostoni, T. Kolobow, G. Damia. - In: JAMA. - ISSN 0098-7484. - 256:7(1986 Aug 15), pp. 881-886.
|Titolo:||Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure|
|Parole Chiave:||Acute disease ; humans ; child ; artificial organs ; saphenous vein ; child preschool ; oxygen ; catheterization ; equipment design ; extracorporeal circulation ; respiratory insufficiency ; lung ; adult ; positive-pressure respiration ; middle aged ; adolescent ; male ; female ; carbon dioxide|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||15-ago-1986|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1001/jama.256.7.881|
|Appare nelle tipologie:||01 - Articolo su periodico|