From Astragalus peregrinus, four cycloartane-type saponins have been isolated and their structures elucidated by spectral means as 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-beta -D-glucopyranoside (1), 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-alpha -L-rhamnopyranosyl-(1 -->4)-beta -D-glucopyranoside (2), 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-alpha -L-rhamnopyranosyl(1 -->2)-beta -D-glucopyranoside (3) and 20(R),25-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,24(S)-tetrol (24-O-acetyl)- 3-O-alpha -L-rhamnopyranosyl-(1 -->2)-(6'-O-acetyl)-beta -D-glucopyranoside (4). Compounds 2 and 3 showed to stimulate the proliferation of mouse splenocytes and were not significantly cytotoxic. (C) 2001 Elsevier Science B.V. All rights reserved.

Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation / L. Verotta, M. Guerrini, N. El-Sebakhy, A. Asaad, S. Toaima, M. Abou-Sheer, Y. Luo, J. Pezzuto. - In: FITOTERAPIA. - ISSN 1971-551X. - 72:8(2001), pp. 894-905.

Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation

L. Verotta
Primo
;
2001

Abstract

From Astragalus peregrinus, four cycloartane-type saponins have been isolated and their structures elucidated by spectral means as 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-beta -D-glucopyranoside (1), 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-alpha -L-rhamnopyranosyl-(1 -->4)-beta -D-glucopyranoside (2), 20(R),24(S)-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,25-tetrol 3-O-alpha -L-rhamnopyranosyl(1 -->2)-beta -D-glucopyranoside (3) and 20(R),25-epoxy-9 beta ,19-cyclolanostane-3 beta ,6 alpha ,16 beta ,24(S)-tetrol (24-O-acetyl)- 3-O-alpha -L-rhamnopyranosyl-(1 -->2)-(6'-O-acetyl)-beta -D-glucopyranoside (4). Compounds 2 and 3 showed to stimulate the proliferation of mouse splenocytes and were not significantly cytotoxic. (C) 2001 Elsevier Science B.V. All rights reserved.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/177095
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