From the roots of Astragalus kahiricus DC., three known saponins, namely, astraversianin VI, astraversianin X, astragaloside VIII, and a new saponin were isolated and identified by spectral data. The structure of the latter was elucidated by spectral means and assigned as cycloastragenol 3-O-[beta-D-(2',3'-diacetyl, 4'-trans-2-butenoyl)-xylopyranosyl], 6-O-beta-D-xylopyranoside (kahiricoside 1). From the aerial parts of A. hamosus L., the known compounds azukisaponin V and peregrinoside I were isolated. As judged by in vitro tests, the saponins isolated from Astragalus spp. endemic to Egypt were not cytotoxic against a variety of human cancer cells. However, dose-related modulation of lymphocyte proliferation was observed, and structure-activity relationships are described.

Cycloartane and oleanane saponins from Egyptian Astragalus spp. as modulators of lymphocyte proliferation / L. Verotta, M. Guerrini, N. El-Sebakhy, A. Assad, S. Toaima, M. Radwan, Y. Luo, J. Pezzuto. - In: PLANTA MEDICA. - ISSN 0032-0943. - 68:11(2002), pp. 986-994.

Cycloartane and oleanane saponins from Egyptian Astragalus spp. as modulators of lymphocyte proliferation

L. Verotta
Primo
;
2002

Abstract

From the roots of Astragalus kahiricus DC., three known saponins, namely, astraversianin VI, astraversianin X, astragaloside VIII, and a new saponin were isolated and identified by spectral data. The structure of the latter was elucidated by spectral means and assigned as cycloastragenol 3-O-[beta-D-(2',3'-diacetyl, 4'-trans-2-butenoyl)-xylopyranosyl], 6-O-beta-D-xylopyranoside (kahiricoside 1). From the aerial parts of A. hamosus L., the known compounds azukisaponin V and peregrinoside I were isolated. As judged by in vitro tests, the saponins isolated from Astragalus spp. endemic to Egypt were not cytotoxic against a variety of human cancer cells. However, dose-related modulation of lymphocyte proliferation was observed, and structure-activity relationships are described.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/177018
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