From the roots of Astragalus kahiricus DC., three known saponins, namely, astraversianin VI, astraversianin X, astragaloside VIII, and a new saponin were isolated and identified by spectral data. The structure of the latter was elucidated by spectral means and assigned as cycloastragenol 3-O-[beta-D-(2',3'-diacetyl, 4'-trans-2-butenoyl)-xylopyranosyl], 6-O-beta-D-xylopyranoside (kahiricoside 1). From the aerial parts of A. hamosus L., the known compounds azukisaponin V and peregrinoside I were isolated. As judged by in vitro tests, the saponins isolated from Astragalus spp. endemic to Egypt were not cytotoxic against a variety of human cancer cells. However, dose-related modulation of lymphocyte proliferation was observed, and structure-activity relationships are described.
|Titolo:||Cycloartane and oleanane saponins from Egyptian Astragalus spp. as modulators of lymphocyte proliferation|
VEROTTA, LUISELLA (Primo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||2002|
|Digital Object Identifier (DOI):||10.1055/s-2002-35654|
|Appare nelle tipologie:||01 - Articolo su periodico|