The effects of intracarotid (i.a.) administration of the histamine (HA) H3-receptor agonist (R)-alpha-methyl-histamine (alpha MeHA) and of the H3-antagonist thioperamide, (THIO) on basal or morphine (M)-induced prolactin (PRL) and growth hormone (GH) secretion were studied in male rats. M was administered 3 h after the H3-drugs. Neither THIO (2.5 mg/kg) nor alpha MeHA (10 mg/kg) changed basal PRL levels and only THIO enhanced the PRL-releasing effect of M (6 mg/kg). Basal GH secretion was not modified by THIO. alpha MeHA slightly increased GH secretion. THIO significantly decreased M-stimulated GH secretion (1 mg/kg, i.a.) and alpha MeHA slightly increased it. These results, in agreement with previous evidence obtained after central HA administration, indicated that endogenous brain HA facilitates PRL and inhibits GH secretion.
|Titolo:||Effects of selective histamine H3-receptor ligands on prolactin and growth hormone secretion in the rat|
GUIDOBONO CAVALCHINI, FRANCESCA (Secondo)
|Parole Chiave:||Animals ; Morphine ; Receptors, Histamine ; Prolactin ; Rats ; Rats, Inbred Strains ; Methylhistamines ; Histamine Antagonists ; Piperidines ; Kinetics ; Receptors, Histamine H3 ; Male ; Growth Hormone|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||mag-1991|
|Digital Object Identifier (DOI):||10.1007/BF01993151|
|Appare nelle tipologie:||01 - Articolo su periodico|