The metabolic derangements of injury are known to influence nitrogen (N) requirements whilst less is known about individual amino acid (AA) requirements. This study was designed to investigate prospectively N vs AA requirement in 36 injured patients treated with total parenteral nutrition (TPN). The non-protein caloric input was 30 kcal kg-1 day-1 and three AA solutions were assessed containing the same AAs but in different proportion. Overall N intake was set at 0.35 g N kg-1 day-1 for solution A and B and 0.24 g N kg-1 day-1 for solution C. Solution B was similar to A, both being enriched in branched chain AAs (BCAA: 0.69 g kg-1 day-1 in B compared with 0.55 g kg-1 day-1 in A) while decreased in aromatic and sulphurated forms (1.75 times the normal need). Solution C was designed to maintain a daily input of BCAA similar to A (0.52 g kg-1 day-1) but with the supply of aromatic and sulphurated AA between solutions A and B, the supply of other AAs (lysine, theonine, histidine, arginine, glycine) being dependent on the selected N intake. For all the essential AAs the supply was always greater than normal allowances. Increasing BCAA over 0.55 g kg-1 day-1 did not improve N balance when N intake was 0.35 g kg-1 day-1, whilst nutrition with solution C was unable to maintain N balance. Moreover we found indirect evidence that this N intake, 0.52 g kg-1 day-1 was more sparing than 0.37 g kg-1 day-1 of BCAA
Essential and non-essential amino acid requirement in injured patients receiving total parenteral nutrition / G. Iapichino, D. Radrizzani, A. Scherini, R. Malacrida, G. Bonetti, L. Leoni, P. Della Torre, G. Ronzoni, A. Colombo, M. Marengo, G. Damia. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 14:4(1988), pp. 399-405.
|Titolo:||Essential and non-essential amino acid requirement in injured patients receiving total parenteral nutrition|
|Parole Chiave:||Amino acid profile; Injury; Nitrogen balance; Nitrogen vs amino acid requirement; TPN|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||1988|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF00262896|
|Appare nelle tipologie:||01 - Articolo su periodico|