The steroid 3, with three independently-addressable, rigidly-positioned functional groups, has been synthesized in an efficient, multi-gram sequence from inexpensive cholic acid 1. Compound 3 should prove valuable as a starting point for combinatorial libraries with preorganised, co-directed arrays of substituents. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
A trifunctional steroid-based scaffold for combinatorial chemistry / J. Barry, A. Davis, M. Perez-Payas, M. Elsegood, R. Jackson, C.M.A. Gennari, U. Piarulli, M. Gude. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 40:14(1999), pp. 2849-2852.
A trifunctional steroid-based scaffold for combinatorial chemistry
C.M.A. Gennari;
1999
Abstract
The steroid 3, with three independently-addressable, rigidly-positioned functional groups, has been synthesized in an efficient, multi-gram sequence from inexpensive cholic acid 1. Compound 3 should prove valuable as a starting point for combinatorial libraries with preorganised, co-directed arrays of substituents. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
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