' Enzymic trap ' experiments show that the main biosynthetic pathway to ascochitine (1) involves the direct reduction of the enzyme-bound ester into aldehyde (4). Therefore the complete pathway has now been assessed. Various synthetic approaches have been tried to synthesize the precursors: the use of 1,3-dithians, of an organolithium equivalent to the Friedel-Crafts reagent, and of phase-transfer reactions allowed for a good introduction of the label.
Biosynthesis of ascochitine and synthesis of its biogenetic precursors / L. Colombo, C.M.A. Gennari, C. Scolastico, F. Aragozzini, C. Merendi. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :11(1980), pp. 2549-2553. [10.1039/P19800002549]
Biosynthesis of ascochitine and synthesis of its biogenetic precursors
C.M.A. Gennari;C. Scolastico;
1980
Abstract
' Enzymic trap ' experiments show that the main biosynthetic pathway to ascochitine (1) involves the direct reduction of the enzyme-bound ester into aldehyde (4). Therefore the complete pathway has now been assessed. Various synthetic approaches have been tried to synthesize the precursors: the use of 1,3-dithians, of an organolithium equivalent to the Friedel-Crafts reagent, and of phase-transfer reactions allowed for a good introduction of the label.Pubblicazioni consigliate
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