Teicoplanin 1 aglycone 1 has been linked to a solid support via two different double cleavable linkers. The attachment was realized selectively on the 38COOH function of 1. Two molecules of 1 were attached on each linker moiety and could be separately released with different mechanisms. The release properties of the resin bound entities were determined by means of analytical and biological characterization.
Combinatorial chemistry and natural products. Teicoplanin aglycon as a molecular scaffold for solid phase synthesis of combinatorial libraries / P. Seneci, C. Sizemore, K. Islam, P. Kocis. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 37:35(1996), pp. 6319-6322. [10.1016/0040-4039(96)01350-0]
Combinatorial chemistry and natural products. Teicoplanin aglycon as a molecular scaffold for solid phase synthesis of combinatorial libraries
P. SeneciPrimo
;
1996
Abstract
Teicoplanin 1 aglycone 1 has been linked to a solid support via two different double cleavable linkers. The attachment was realized selectively on the 38COOH function of 1. Two molecules of 1 were attached on each linker moiety and could be separately released with different mechanisms. The release properties of the resin bound entities were determined by means of analytical and biological characterization.
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