Teicoplanin 1 aglycone 1 has been linked to a solid support via two different double cleavable linkers. The attachment was realized selectively on the 38COOH function of 1. Two molecules of 1 were attached on each linker moiety and could be separately released with different mechanisms. The release properties of the resin bound entities were determined by means of analytical and biological characterization.
Combinatorial chemistry and natural products. Teicoplanin aglycon as a molecular scaffold for solid phase synthesis of combinatorial libraries / P. Seneci, C. Sizemore, K. Islam, P. Kocis. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 37:35(1996), pp. 6319-6322.
|Titolo:||Combinatorial chemistry and natural products. Teicoplanin aglycon as a molecular scaffold for solid phase synthesis of combinatorial libraries|
SENECI, PIERFAUSTO (Primo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0040-4039(96)01350-0|
|Appare nelle tipologie:||01 - Articolo su periodico|